Deciphering Human Chromosome 16: Index to the Report collects views on nature, genetics, and the deciphering of human chromosome 16, as culled from various websites in the months following the 2004 publication in the journal Nature of “The Sequence and Analysis of Duplication-Rich Human Chromosome 16.” Jacobs sets these written fragments against the earlier draft sequence originally published by Project Gutenberg, using text in a visual way to document the ethical, economic, political and philosophical polemics associated with mapping the human genome. The solid physicality of the Index contrasts with the ever-changing Report, although fluctuations inherent in the print-on-demand process in which the book is made ensure that each copy of the Index is unique.